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Theramir Secures €525,000 To Propel Cancer Therapy To Clinical Phase

In a significant boost to its pioneering cancer treatment research, Theramir has successfully raised €525,000 in a bridge funding round. This capital injection is poised to support the company’s operations through the latter half of 2025, targeting a critical milestone: the initiation of clinical trials for their innovative therapy, EVmiR.

EVmiR, now patented by the European Patent Office, represents a novel approach in cancer treatment. By utilising extracellular vesicles (EVs) to deliver microRNAs (miRNAs) directly into tumours, Theramir aims to target oncoproteins—key regulators of cancer cell growth. This precision method promises fewer side effects compared to traditional treatments such as chemotherapy. The company’s technology has demonstrated efficacy in treating metastatic breast cancer and is now being tested for pancreatic and bladder cancers.

Theramir, co-founded by Marianna Prokopi-Demetriades and Costas Pitsillides in 2016, emerged from a passionate pursuit to find a cure for cancer. Their unique technology capitalises on EVs’ natural ability to transport biological information, essentially turning them into couriers that deliver tumour-suppressive messages via miRNAs. This method requires a detailed genetic profile of the patient to enhance the therapy’s precision and effectiveness, potentially offering prophylactic benefits by identifying genetic markers linked to high-risk conditions.

The latest funding round saw participation from notable investors, including Yannos Palate, a former executive at Eli Lilly, who will join Theramir’s advisory board. His extensive experience in life sciences and pharmaceutical engagement is expected to be instrumental in forging strategic partnerships with major pharmaceutical companies. Other investors include Nicosia-based family office Exerte Partners and finance and corporate lawyer Nancy Erotocritou.

Despite the challenges posed by the limited local life-sciences ecosystem in Cyprus, Theramir has managed to attract significant investor interest, raising €2.5 million in total, including €300,000 in grants. The company’s innovative approach and lower research costs compared to major biotech hubs like Boston or London have contributed to its success.

Looking ahead, Theramir is actively seeking a licensing deal with a major pharmaceutical firm to support the clinical trials, which could span up to seven years. The co-founders are optimistic about expediting the timeline through process efficiencies, projecting a market-ready therapy by 2030. In the interim, they are also exploring new revenue streams, such as using EVmiR to treat chronic malignant wounds through a project named MIRACULOUS, which has secured additional funding.

Cybersecurity Is No Longer Enough As Corporate Threats Expand

Cyber threats are becoming harder to separate from wider risks facing businesses, their leaders and employees. A European Commission-backed survey cited by Euronews found that three in four employees had encountered suspicious emails, messages or links at work. Nearly four in 10 reported phishing attempts or redirection to fake websites designed to steal data or gain unauthorised access. Others had encountered attempts to obtain personal information, deploy malware or steal passwords.

For businesses, however, digital attacks are only part of a much broader security challenge. Organisations must increasingly prepare for threats that span online activity, internal misconduct and physical harm.

Beyond Cybercrime: A Wider Threat Landscape

Companies, executives and employees face risks from organised criminal groups, hostile state actors, insiders and individual attackers. While some threats involve ransomware, stolen credentials or data breaches, others can escalate into stalking, harassment, kidnapping or violence against senior leaders and their families.

This convergence of digital and physical risks is forcing businesses to rethink security as a broader strategic responsibility rather than a function focused primarily on IT systems.

Insider Threats Carry A Growing Cost

Current and former employees can pose significant risks when they misuse privileged access, steal data or sabotage systems. According to a Ponemon Institute report cited in the original article, the average total cost of insider threat incidents rose by approximately 135% between 2018 and 2025.

North America recorded the highest average annual cost in 2025, at $24 million, while Europe followed at $18.6 million. These figures highlight the financial consequences of internal security failures, which can undermine business continuity, damage reputations and affect earnings.

Executives And Their Families Face Greater Exposure

Security concerns are also becoming more personal. The 2024 killing of UnitedHealthcare CEO Brian Thompson in the United States demonstrated how grievances can escalate into violence against corporate leaders. Europe has experienced similar concerns, including the attempted kidnapping of the daughter of French cryptocurrency executive Pierre Noizat last year.

A survey by the International Security Management Association (ISMA) found that more than half of chief security officers reported that their organisations’ senior executives or family members received up to nine direct threats of harm each year through online, telephone, written or other channels.

Public records, social media and AI-enabled research can make it easier for attackers to gather sensitive information without sophisticated intelligence networks. Family members’ online activity may reveal personal details, while publicly available data can be combined to build a more complete picture of an executive’s life. One study cited in the original article found that home addresses were publicly discoverable in 94% of executive vulnerability assessments.

Economic Uncertainty And Political Division Add To Risk

Traditional threat models are struggling to account for an environment in which the path from grievance to action can be difficult to predict. Economic pressures and political anger can converge, with businesses and their leaders becoming visible targets for wider frustration.

In a survey of more than 2,300 security chiefs across 31 countries, Allied Universal found that 44% expected economic instability to be the leading security hazard in the year ahead. Political polarisation adds another layer of uncertainty: a 2024 Littler report found that 86% of European employers faced at least some difficulty managing divisive political beliefs in the workplace, up from 75% a year earlier.

Corporate announcements, restructuring decisions and executives’ public positions can all become flashpoints in a tense environment.

Threat Assessment Must Become A Boardroom Priority

Responding to these risks requires more than perimeter security. Companies need to identify potential triggers that could provoke strong reactions, from profit warnings and workforce reductions to decisions to halt research funding or public statements on political issues.

Mapping these pressure points requires cooperation between boards and security teams. Rather than treating threat assessment as a purely operational task, organisations need to anticipate how business decisions may affect their exposure and how quickly a situation could escalate.

AI Is Becoming Part Of The Security Response

Artificial intelligence can help security teams identify patterns and respond more quickly. Potential applications include CCTV object recognition, facial recognition, social media monitoring, weapon detection and predictive analysis.

Technology alone, however, cannot address the full range of risks. Cybersecurity remains essential, but it must form part of a broader framework covering insider threats, executive protection, physical security and political volatility.

As Europe marks cybersecurity month, the challenge for business leaders is to recognise how closely these risks are connected. Security is no longer simply a back-office function; it is an increasingly important part of corporate resilience and strategic decision-making.

ISMA, the International Security Management Association, is a global membership organisation for senior chief security officers at multinational companies. Founded in 1983, it has approximately 375 members, including executives from 25 companies in the FTSE 100, DAX and CAC 40, as well as a majority of Fortune 100 companies and 25% of the Fortune 500. Its members include security leaders from MetLife, S&P Global, Sky, Four Seasons, Unilever and Novo Nordisk.Cyber threats are becoming harder to separate from wider risks facing businesses, their leaders and employees. A European Commission-backed survey cited by Euronews found that three in four employees had encountered suspicious emails, messages or links at work. Nearly four in 10 reported phishing attempts or redirection to fake websites designed to steal data or gain unauthorised access. Others had encountered attempts to obtain personal information, deploy malware or steal passwords.

For businesses, however, digital attacks are only part of a much broader security challenge. Organisations must increasingly prepare for threats that span online activity, internal misconduct and physical harm.

Beyond Cybercrime: A Wider Threat Landscape

Companies, executives and employees face risks from organised criminal groups, hostile state actors, insiders and individual attackers. While some threats involve ransomware, stolen credentials or data breaches, others can escalate into stalking, harassment, kidnapping or violence against senior leaders and their families.

This convergence of digital and physical risks is forcing businesses to rethink security as a broader strategic responsibility rather than a function focused primarily on IT systems.

Insider Threats Carry A Growing Cost

Current and former employees can pose significant risks when they misuse privileged access, steal data or sabotage systems. According to a Ponemon Institute report cited in the original article, the average total cost of insider threat incidents rose by approximately 135% between 2018 and 2025.

North America recorded the highest average annual cost in 2025, at $24 million, while Europe followed at $18.6 million. These figures highlight the financial consequences of internal security failures, which can undermine business continuity, damage reputations and affect earnings.

Executives And Their Families Face Greater Exposure

Security concerns are also becoming more personal. The 2024 killing of UnitedHealthcare CEO Brian Thompson in the United States demonstrated how grievances can escalate into violence against corporate leaders. Europe has experienced similar concerns, including the attempted kidnapping of the daughter of French cryptocurrency executive Pierre Noizat last year.

A survey by the International Security Management Association (ISMA) found that more than half of chief security officers reported that their organisations’ senior executives or family members received up to nine direct threats of harm each year through online, telephone, written or other channels.

Public records, social media and AI-enabled research can make it easier for attackers to gather sensitive information without sophisticated intelligence networks. Family members’ online activity may reveal personal details, while publicly available data can be combined to build a more complete picture of an executive’s life. One study cited in the original article found that home addresses were publicly discoverable in 94% of executive vulnerability assessments.

Economic Uncertainty And Political Division Add To Risk

Traditional threat models are struggling to account for an environment in which the path from grievance to action can be difficult to predict. Economic pressures and political anger can converge, with businesses and their leaders becoming visible targets for wider frustration.

In a survey of more than 2,300 security chiefs across 31 countries, Allied Universal found that 44% expected economic instability to be the leading security hazard in the year ahead. Political polarisation adds another layer of uncertainty: a 2024 Littler report found that 86% of European employers faced at least some difficulty managing divisive political beliefs in the workplace, up from 75% a year earlier.

Corporate announcements, restructuring decisions and executives’ public positions can all become flashpoints in a tense environment.

Threat Assessment Must Become A Boardroom Priority

Responding to these risks requires more than perimeter security. Companies need to identify potential triggers that could provoke strong reactions, from profit warnings and workforce reductions to decisions to halt research funding or public statements on political issues.

Mapping these pressure points requires cooperation between boards and security teams. Rather than treating threat assessment as a purely operational task, organisations need to anticipate how business decisions may affect their exposure and how quickly a situation could escalate.

AI Is Becoming Part Of The Security Response

Artificial intelligence can help security teams identify patterns and respond more quickly. Potential applications include CCTV object recognition, facial recognition, social media monitoring, weapon detection and predictive analysis.

Technology alone, however, cannot address the full range of risks. Cybersecurity remains essential, but it must form part of a broader framework covering insider threats, executive protection, physical security and political volatility.

As Europe marks cybersecurity month, the challenge for business leaders is to recognise how closely these risks are connected. Security is no longer simply a back-office function; it is an increasingly important part of corporate resilience and strategic decision-making.

ISMA, the International Security Management Association, is a global membership organisation for senior chief security officers at multinational companies. Founded in 1983, it has approximately 375 members, including executives from 25 companies in the FTSE 100, DAX and CAC 40, as well as a majority of Fortune 100 companies and 25% of the Fortune 500. Its members include security leaders from MetLife, S&P Global, Sky, Four Seasons, Unilever and Novo Nordisk.

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