Cyprus and Israel Join Forces For Groundbreaking Gene Editing Project

by News Editor

March 31, 2025

The Molecular Genetics Thalassaemia Department at the Cyprus Institute of Neurology & Genetics (CING) has launched EDIT-4-IRON, an ambitious genome editing initiative aimed at transforming treatments for iron-related blood disorders.

Backed by a €200,000 grant under the “RESTART 2016–2020, Bilateral Collaborations” program from the Research and Innovation Foundation, this 36-month project strengthens scientific ties between Cyprus and Israel while reinforcing both nations’ positions as leaders in genetic and haematological research.

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A Pioneering Collaboration

Led by Dr. Carsten W. Lederer, Head of the MGTD and Associate Professor at CING, the Cypriot team includes haematologist Dr. Panayiota L. Papasavva and gene editing expert Dr. Petros Patsali. On the Israeli side, gene editing specialist Dr. Ayal Hendel, a professor at Bar-Ilan University (BIU), spearheads the project.

Both institutions bring extensive expertise to the table. CING, the national reference laboratory for rare anaemia research and diagnosis in Cyprus, has been at the forefront of gene therapy innovations. BIU, meanwhile, holds multiple patents in editing technology and is a national leader in advanced therapy medicinal product development for blood disorders.

Training The Next Generation

Beyond its scientific breakthroughs, EDIT-4-IRON will provide cutting-edge training opportunities. The project supports two PhD students—one in Cyprus (Azzam Mohamed Ahmed Abdelfattah) and one in Israel—alongside an MSc student in Israel, offering them hands-on experience in gene therapy technologies and international networking prospects.

A Revolutionary Approach To Iron Disorders

EDIT-4-IRON aims to revolutionise treatments for inherited and acquired iron-related haematological disorders (IHDs), such as transfusion-dependent β-thalassaemia, non-transfusion-dependent thalassaemia, hereditary haemochromatosis, and polycythaemia vera. These conditions, often marked by iron overload or ineffective erythropoiesis, currently rely on small-molecule therapies that require lifelong administration and come with significant side effects.

By leveraging CRISPR/Cas and base editing technologies, researchers aim to create gene knockouts that induce an iron-restrictive state, potentially offering a long-term therapeutic alternative for thousands of patients worldwide.

A Data-Driven Approach

The project will rigorously evaluate the safety and efficacy of these gene-editing strategies through ex vivo and in vivo testing, using primary patient samples from Cyprus, cell lines, and murine disease models. This approach ensures that any breakthroughs can be translated into real-world clinical applications.

Setting the Stage For Innovation

EDIT-4-IRON officially kicked off on May 26, 2025, with a meeting between the Cypriot and Israeli teams to define collaboration frameworks, project milestones, and deliverables. With its combination of groundbreaking science, international cooperation, and a commitment to patient-centric innovation, this project marks a significant step forward in the fight against iron-related blood disorders.

The Future Forbes Realty Global Properties

€50 Million Luxury Resort Planned For Ayia Napa

by THEFUTURE.TEAM

October 22, 2026

Ayia Napa could strengthen its position in the premium tourism market with a proposed €50 million mixed-use resort combining a hotel, serviced apartments, luxury bungalows and a beach club.

Aesara Investments Ltd has submitted an information form to the Department of Environment for a development to operate under the name Atlantica Wavemaster Hospitality. The project is planned for the Limnara area of Ayia Napa, along the coast south of Kryou Nerou Avenue, between the town centre and Cape Greco.

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Hotel, Apartments And Luxury Bungalows

The proposed resort will include a 324-room hotel with capacity for 648 guests, alongside a condo-hotel building containing 20 one- and two-bedroom apartments. Facilities are planned to include restaurants, bars, cafés, a spa with an indoor pool, a gym, shops, a multipurpose hall, a children’s club and a cinema.

A further 33 three-level luxury bungalows, each designed for two guests and featuring a private swimming pool, are planned for the southern part of the site. A beach club with a restaurant and an outdoor pool complex covering more than 6,300 square metres will also form part of the development.

The project includes 321 parking spaces, including 12 for people with disabilities, and 14,196 square metres of landscaped green space featuring local plant species.

Seasonal Hotel Operations And Year-Round Residences

The hotel is expected to operate from March to November, with peak occupancy during the summer season. The condo-hotel apartments, meanwhile, will be available for sale or long-term rental and intended for year-round residence. Owners and tenants will also have access to the resort’s facilities, including its pools, restaurants and fitness areas.

Construction is expected to take 24 months once the required permits are secured. At the busiest stage, the project could employ around 100 workers per day.

Environmental Restrictions Near Cape Greco

The site’s proximity to protected Natura 2000 areas has prompted strict environmental requirements. The Cape Greco Special Protection Area borders the site to the south, while a Special Area of Conservation lies approximately 50 metres away.

Conditions imposed by the Department of Environment include a maximum building height of five floors, or 18.5 metres, and restrictions on permanent structures near the coastline. The project must also use spider-web type glazing and low-intensity lighting to minimise disturbance to local birdlife.

According to the project’s consultants, the design has been prepared to comply with the environmental conditions and the final report on cumulative impacts for the Cape Greco Special Protection Area. The hotel and apartment building are positioned in the central and northern parts of the plot, away from the shoreline.

Within the designated no-build zone, located 40 metres from the boundary of the beach protection zone, only swimming pools are planned. The consultants state that these are not expected to affect protected species in the area.

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