Cyprus and Israel Join Forces For Groundbreaking Gene Editing Project

by News Editor

March 31, 2025

The Molecular Genetics Thalassaemia Department at the Cyprus Institute of Neurology & Genetics (CING) has launched EDIT-4-IRON, an ambitious genome editing initiative aimed at transforming treatments for iron-related blood disorders.

Backed by a €200,000 grant under the “RESTART 2016–2020, Bilateral Collaborations” program from the Research and Innovation Foundation, this 36-month project strengthens scientific ties between Cyprus and Israel while reinforcing both nations’ positions as leaders in genetic and haematological research.

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A Pioneering Collaboration

Led by Dr. Carsten W. Lederer, Head of the MGTD and Associate Professor at CING, the Cypriot team includes haematologist Dr. Panayiota L. Papasavva and gene editing expert Dr. Petros Patsali. On the Israeli side, gene editing specialist Dr. Ayal Hendel, a professor at Bar-Ilan University (BIU), spearheads the project.

Both institutions bring extensive expertise to the table. CING, the national reference laboratory for rare anaemia research and diagnosis in Cyprus, has been at the forefront of gene therapy innovations. BIU, meanwhile, holds multiple patents in editing technology and is a national leader in advanced therapy medicinal product development for blood disorders.

Training The Next Generation

Beyond its scientific breakthroughs, EDIT-4-IRON will provide cutting-edge training opportunities. The project supports two PhD students—one in Cyprus (Azzam Mohamed Ahmed Abdelfattah) and one in Israel—alongside an MSc student in Israel, offering them hands-on experience in gene therapy technologies and international networking prospects.

A Revolutionary Approach To Iron Disorders

EDIT-4-IRON aims to revolutionise treatments for inherited and acquired iron-related haematological disorders (IHDs), such as transfusion-dependent β-thalassaemia, non-transfusion-dependent thalassaemia, hereditary haemochromatosis, and polycythaemia vera. These conditions, often marked by iron overload or ineffective erythropoiesis, currently rely on small-molecule therapies that require lifelong administration and come with significant side effects.

By leveraging CRISPR/Cas and base editing technologies, researchers aim to create gene knockouts that induce an iron-restrictive state, potentially offering a long-term therapeutic alternative for thousands of patients worldwide.

A Data-Driven Approach

The project will rigorously evaluate the safety and efficacy of these gene-editing strategies through ex vivo and in vivo testing, using primary patient samples from Cyprus, cell lines, and murine disease models. This approach ensures that any breakthroughs can be translated into real-world clinical applications.

Setting the Stage For Innovation

EDIT-4-IRON officially kicked off on May 26, 2025, with a meeting between the Cypriot and Israeli teams to define collaboration frameworks, project milestones, and deliverables. With its combination of groundbreaking science, international cooperation, and a commitment to patient-centric innovation, this project marks a significant step forward in the fight against iron-related blood disorders.

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Strained Household Finances: Eurostat Data Reveals Persistent Payment Delays Across Europe and in Cyprus

by THEFUTURE.TEAM

November 22, 2025

Improved Financial Resilience Amid Ongoing Strains

Over the past decade, Cypriot households have significantly increased their ability to manage debts—not only bank loans but also rent and utility bills. However, recent Eurostat data indicates that Cyprus continues to lag behind the European average when it comes to covering financial obligations on time.

Household Coping Strategies and the Limits of Payment Flexibility

While many families are managing their fixed expenses with relative ease, one in three Cypriots struggles to cover unexpected costs. This delicate balancing act highlights how routine payments such as mortgage installments, rent, and utility bills are met, but precariously so, with little room for unplanned financial shocks.

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Breaking Down Payment Delays Across the European Union

Eurostat reports that nearly 9.2% of the EU population experienced delays with their housing loans, rent, utility bills, or installment payments in 2024. The situation is more acute among vulnerable groups: 17.2% of individuals in single-parent households with dependent children and 16.6% in households with two adults managing three or more dependents faced payment delays. In every EU nation, single-parent households exhibited higher delay rates compared to the overall population.

Cyprus in the Crosshairs: High Rates of Financial Delays

Although Cyprus recorded a notable 19.1 percentage point improvement from 2015 to 2024 in delays related to mortgages, rent, and utility bills, the island nation still ranks among the top five countries with the highest delay rates. As of 2024, 12.5% of the Cypriot population had outstanding housing loans or rent and overdue utility bills. In contrast, Greece tops the list with 42.8%, followed by Bulgaria (18.7%), Romania (15.3%), Spain (14.2%), and other EU members. Notably, 19 out of 27 EU countries reported delay rates below 10%, with Czech Republic (3.4%) and Netherlands (3.9%) leading the pack.

Selective Improvements and Emerging Concerns

Between 2015 and 2024, the overall EU population saw a 2.6 percentage point decline in payment delays. Despite this, certain countries experienced increases: Luxembourg (+3.3 percentage points), Spain (+2.5 percentage points), and Germany (+2.0 percentage points) saw a rise in payment delays, reflecting underlying economic pressures that continue to challenge financial stability.

Economic Insecurity and the Unprepared for Emergencies

Another critical indicator explored by Eurostat is the prevalence of economic insecurity—the proportion of the population unable to handle unexpected financial expenses. In 2024, 30% of the EU population reported being unable to cover unforeseen costs, a modest improvement of 1.2 percentage points from 2023 and a significant 7.4 percentage point drop compared to a decade ago. In Cyprus, while 34.8% still report difficulty handling emergencies, this marks a drastic improvement from 2015, when the figure stood at 60.5%.

A Broader EU Perspective

Importantly, no EU country in 2024 had more than half of its population facing economic insecurity—a notable improvement from 2015, when over 50% of the population in nine countries reported such challenges. These figures underscore both progress and persistent vulnerabilities within European households, urging policymakers to consider targeted measures for enhancing financial resilience.

For further insights and detailed analysis, refer to the original reports on Philenews and Housing Loans.

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